Are you starting to notice the effect that aging has on your muscular growth and strength? Can’t seem to perform or recover from an exercise routine quickly? Aging tends to deplete a number of the body’s usual productions. In men’s health, the body responds less to protein intake and physical activity because of its inability to digest food efficiently, changes to muscle fibers and the nervous system, possible hormone imbalances, and prolonged muscle recovery. Stated differently, men have a lot going on in their later years, warranting changes to their diet and exercise routines.

Dr. Tracy Gapin understands the toll aging has on men’s health, as he, too, hit rock bottom at some point. The difference is the moment he fell, he sought help to recover. Since then, he has advocated for aging management, helping athletes understand their bodies better and providing tailored solutions. Realizing how common anabolic resistance is, his company, Apex Labs, developed a formula that could put men back on track to becoming more robust, more energized, and feeling years younger than they presently are. This is where it is fitting to introduce Muscle Defense.

What is Muscle Defense?

Muscle Defense is an advanced muscle-building, fat-burning supplement to help men overcome anabolic resistance. Anabolic resistance is defined as a resistance to muscle protein synthesis. In other words, for a given dose of amino acids and protein, there is a reduction in new muscle proteins, thereby decreasing skeletal muscle mass. Usually, the combination of physical inactivity and aging exacerbates this issue, preventing men from building muscles. The creators of Muscle Defense, Apex Labs, insist that when this supplement is taken as advised, it can potentially support strong, healthy muscles and a leaner body.

It is astounding that the aforementioned can be accomplished without the use of steroids, testosterone, or controlled substances. Considering everything, we believe everyone should have a strong understanding of exactly what each ingredient does in the body. The following section will cover each ingredient, its various properties, and its overall importance in Muscle Defense.

What ingredients are in Muscle Defense?

The main ingredients in Muscle Defense are:

Hydrolyzed Whey Protein (10,000 mg)

Whey protein is defined as a mixture of proteins isolated from the liquid part of milk during cheese production. Milk contains two types of protein: casein (80%) and whey (20%), with whey being the watery portion of milk. In Muscle Defense’s case, the protein has been broken down enough for easier digestion when whey is hydrolyzed. That said, whey protein has been shown to promote muscle strength and gain by serving as building blocks, increasing the release of anabolic hormones for muscle growth (insulin being one of them), and increasing leucine content (essential for stimulating muscle protein synthesis).

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After digging further into matters, our editorial arrived at a source that highlighted key facets of hydrolyzed whey protein. It underscored that it might promote faster recovery, especially after high-intensity training, and significantly increase insulin response (which is believed to stimulate muscle growth).

L-Leucine (1,000 mg)

L-leucine is an essential branched-chain amino acid (BCAA). It is found naturally in poultry and dairy products and is also available as a dietary supplement. In the context of muscle health, the same source emphasized that L-leucine has some potential for promoting muscle growth and recovery. This stems from the BCAA’s ability to activate the mTOR signaling pathway. That said, results are generally mixed, with the BCAA exhibiting the most health benefits to older adults, namely, those suffering from age-related muscle loss.

A 2024 study of healthy Korean adults 50 and older found that L-leucine, combined with a strength training protocol, significantly improved lean muscle mass. Another study was referenced to discuss muscle recovery, highlighting that leucine-enriched amino acids might reduce muscle damage days after resistance exercise. Other possible benefits of taking L-leucine include reduced inflammation and stabilized blood sugar levels.

Vitamin D3 (50 mcg)

Vitamin D3 is the active or more bioavailable form of vitamin D, meaning the body can efficiently absorb it. Found in foods such as fish, beef livers, eggs, and cheeses, vitamin D3 production is also induced upon sun exposure. What does vitamin D3 mean for Muscle Defense? From the looks, this vitamin directly contributes to “skeletal muscle function […] cell proliferation, differentiation, regulation of protein synthesis, and mitochondrial metabolism,” writes another source. All in all, it has the potential to enhance exercise performance by ensuring the conversion of glucose into energy and regulating healthy muscle contractions.

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HMB (1,000 mg)

Hydroxymethylbutyrate (HMB) is a substance the body naturally produces upon breaking down L-leucine. Supplementation is usually sought after since the body only produces HMB in small concentrations. In terms of consumption, it is a favorite among athletes and fitness enthusiasts hoping to improve their performance and overall muscle growth. Based on relatively outdated studies, HMB generally strongly affected untrained and older people. Unfortunately, studies remain mixed, with some suggesting that HMB is helpful when combined with exercise, while others report insignificant results.

Another way in which HMB might work is by reducing the breakdown of muscles. In particular, researchers have reported inhibited muscle breakdown on a cellular level by suppressing genes and enzymes linked to breakdown. Other possible results include increased adaptations to exercise (i.e., aerobic exercise capacity and peak anaerobic power) and reduced body fat. But again, more quality research is needed to arrive at a strong conclusion about its effectiveness.

Velositol® (1,000 mg)

Velositol® is a patented complex of amylopectin (a branched carbohydrate) and chromium. This complex is believed to increase strength and power by boosting muscle protein synthesis when taken alongside protein. So far, it has 11 patents and pending applications, six supporting research studies, and is found in over 25 consumer brands. Concerning specific areas of physical improvement, Velositol® is believed to improve strength, jump power, and muscle endurance in as early as four weeks while doubling squat reps to failure. As per the developers, Nutrition21, Velositol® also has the potential to enhance insulinogenic function.

By increasing insulin function, this complex supposedly increases amino acid uptake as well. This fuels working muscles, thereby helping people get the most from their workouts. When paired with a healthy diet and exercise, individuals can also expect reduced body fat, lean muscle mass, and healthy blood lipid metabolism, among other things.

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Ursolic Acid (50 mg) & Loquat Leaf Extract (40 mg)

Ursolic acid (UA) is a natural triterpene derived from fruits and vegetables. Based on a review of its properties, triterpene is renowned for its anti-inflammatory, antioxidant, anti-apoptotic, and anti-carcinogenic effects. It mainly works by suppressing nuclear factor-kappa B (NF-KB) signaling, which alone improves insulin signaling in fat tissues, reduces markers linked to cardiac damage, and lowers inflammation, to name a few. Interestingly, taking a dose of 150 mg daily before breakfast for 12 weeks resulted in significant reductions in body weight, body mass index (BMI), waist circumference, and fasting blood sugar levels.

As for brain health, UA has been demonstrated to inhibit oxidative stress and excitotoxicity; both have been shown to create an imbalance in cellular homeostasis, consequently reducing cognitive function and inducing brain damage. Doses for this area of health vary from 5 and 50 mg for at least a full day to 2 months. Finally, when it comes to exercise performance, UA is said to improve exercise capacity and decrease resting heart rate. These results might be because of the triterpene’s ability to stimulate specific expressions in the body, supporting both skeletal muscle synthesis and hypertrophy.

Another ingredient worth mentioning at this point is the loquat leaf extract. Loquat is a subtropical tree native to China. Its fruit and leaves have been historically used to treat various health conditions, as they contain anti-inflammatory, antioxidant, anti-bacterial, and analgesic properties. Remarkably, this ingredient also happens to be a rich source of ursolic acid, which, as covered above, has the potential to prevent skeletal muscle atrophy and improve exercise capacity.

A more recent study that examined the effects of loquat leaf extract in a rat model underlined its ability to enhance muscle contraction-induced activation. This is essential for activating various signaling pathways (mTOR being one of them), releasing growth factors (known to stimulate muscle protein synthesis), and promoting muscle repair and growth. More research with human subjects is still needed to confirm this angle.

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Vitamin B12 (1.5 mcg)

Vitamin B12 (or cobalamin) is a vitamin that is naturally found in certain foods. It is essential for red blood cell and DNA production and the proper functioning of brain and nerve cells. Moreover, it might improve exercise performance paired with other B vitamins (specifically B1, B2, and B6). In particular, researchers reported an increase in running time by 1.26-fold and a reduction in blood lactate and ammonia concentrations during and after exercise. The latter means that, after exercise, lactate and ammonia are removed from the body, which is critical for recovery and preparing for the next exercise session.

How much does Muscle Defense cost?

Each Muscle Defense pouch offers 15 servings (1 scoop = 16.85 grams), lasting less than a month. For those who are interested in continuing this brand in the interim, the following price options have been made available:

• 1-month supply of Muscle Defense (2 pouches): $49.95/pouch
• 2-month supply of Muscle Defense (4 pouches): $44.95/pouch
• 3-month supply of Muscle Defense (6 pouches): $39.95/pouch

A 60-day money-back guarantee covers all orders. Contact customer service if you have any questions about the return policy or anything else.

• Email: support@apexlaboratories.com.
• Telephone: 1-833-234-3939

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About Apex Labs

Apex Labs is a health and wellness supplement provider on a mission to help people understand the importance of their health and pave a path in which people are actively working toward protecting their health. Founder Dr. Tracy Gapin, MD, set up Apex Labs after enduring several health consequences. In his letter, he shared how, 11 years ago, he was 30 pounds overweight, had a cholesterol of 245, and felt sexually weak. At the time, he was quite embarrassed to say he was a doctor who didn’t even consider his well-being—failing to look after himself snowballed into several problems, eventually impacting his career and relationships.

It got to a point where he had to seek other doctors’ opinions, only to realize that he was prescribed pricy pills that made him feel worse. Everywhere he looked, he saw men face a similar situation: “men suffering from low T, low confidence, feeling weak, old, and, well, soft.” Naturally, this led him on a two-decade journey of researching men’s health and helping men become the best possible versions of themselves. At the time, he set up his clinic, The Gapin Institute, providing personalized health advice.

Since this journey unfolded, the founder lost 20 pounds, experienced a resurge in sexual drive, and felt 15 years younger. At this point, he realized that yearning to provide for a loved one starts by prioritizing one’s health. Thus, Apex Labs was born. Here is an extract from Dr. Tracy Gapin’s letter on the contribution of Apex Labs to men’s health:

“With Apex Labs, I’m honored to give you access to my secrets, which have helped CEOs, world-beating athletes, and visionary entrepreneurs perform at the highest level. Each formula is created using the latest scientific research […], All with one goal: “To help you become the man you – and your loved ones – deserve.”

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Listed below are some of Dr. Tracy Gapin’s career accomplishments, accreditations, and affiliations:

• Board-certified urologist
• Best-selling health author
• Member of the American Academy of Aging, Age Management Medical Group, and International Peptide Society
• CEO of the Gapin Institute for High-Performance Health
• CEO and founder of Apex Labs
• Featured on TEDx, SRQ Media, WFLA News Channel 8, and Entrepreneur
• Publication 1: Male 2.0: Cracking the Code to Limitless Health and Vitality
• Publication 2: Codes of Longevity: Learn from 20+ of Today’s Leading Health Experts

Frequently Asked Questions (FAQ)

Q: Is Muscle Defense safe?

A: Muscle Defense appears safe because it contains ingredients typically found in protein supplements. Moreover, research has generally reported good tolerance with little to no side effects. That said, whey protein might cause digestive issues, but this seems unlikely given that Muscle Defense contains hydrolyzed whey protein. Before adding anything new to an existing regimen, individuals are encouraged to do their due diligence and seek a healthcare practitioner if needed.

Q: Is Muscle Defense legal?

A: Yes, Muscle Defense is legal in all American states. The formula is free from steroids, testosterone, and controlled substances. In fact, the creators insist that they used only “clinically proven compounds to help you build muscle and torch fat.”

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Q: How do I take Muscle Defense?

A: To make the most of Muscle Defense, individuals should add one scoop to a glass of water until evenly blended. It can be consumed as a pre-or post-workout snack alongside breakfast, lunch, or dinner.

Q: Can women take Muscle Defense as well?

A: Women can take Muscle Defense as well, as this group is also at risk of experiencing age-related muscle loss. Based on available studies, most included men, which might explain Apex Labs’ target. But this is not to say that women might not see similar results.

Q: How many calories are there in each Muscle Defense serving?

A: Each serving contains 59 calories, of which 3.8 grams represent carbohydrates and 10 grams represent protein.

Q: What types of results can I expect from Muscle Defense?

A: Muscle Defense has the potential to help men of all ages maintain and gain lean mass, burn fat, and improve their strength over time.

Q: How long will it take to see results with Muscle Defense?

A: Muscle Defense is believed to provide desirable results when taken consistently. This means pairing the supplement with a healthy diet and workout routine. For the best possible results, the Apex Labs team recommends taking Muscle Defense for at least the first two months before evaluating its effectiveness. This timeframe should give the nutrients in this formula enough time to positively impact muscle and fat levels.

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Q: What does Muscle Defense taste like?

A: Muscle Defense is vanilla-flavored.

Q: How long will it take for Muscle Defense shipments to arrive?

A: Muscle Defense shipments to the contiguous United States should take 5 to 7 business days. The website suggests a similar timeline for international orders, but it might be a good idea to confirm this with the customer support team before placing an order.

Q: Does a money-back guarantee protect Muscle Defense?

A: Muscle Defense has been protected by a 60-day money-back guarantee. To be eligible for the return, the original pouch must be returned within 60 days from the date of purchase. At the time of writing, it is unclear whether Apex Labs accepts used and unused pouches. For more clarification, the team can be reached at:

• Email: support@apexlaboratories.com.
• Telephone: 1-833-234-3939

Final Verdict

Based on the above comprehensive review, it should be clear that Muscle Defense focuses on increasing anabolic health, primarily in the aging male population. As emphasized by the CEO, Dr. Tracy Gapin, age-related anabolic resistance not only takes a hit to men’s skeletal muscle mass but also their sexual drive, strength, physical performance, and eventually, their mental performance. As someone who has previously experienced all of those above and neglected his health, Dr. Tracy Gapin wants men to rethink their choices and revamp their nutrition. In this case, Muscle Defense would be considered an adjunct to a healthy diet and exercise routine.

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Our research on the ingredients suggests that Muscle Defense focuses on maintaining healthy BCAA and protein levels in the body and stimulating growth factor hormones. Together, these factors are believed to stimulate muscle protein synthesis, exercise performance, and muscle recovery. L-leucine is central to the previously noted goals, with several ingredients working to ensure that the body fully absorbs BCAA to reap its benefits. Moreover, each serving has been equipped with hydrolyzed whey protein and ingredients high in ursolic acid.

As we all know, the former contributes to protein synthesis and muscle recovery. In contrast, the latter has a wide range of properties that exceed these goals (i.e., anti-inflammatory, antioxidant, anti-bacterial, etc.). How can anyone overlook some of the more straightforward vitamins that positively affect overall wellness, whether it be for men or women? That said, our editorial team liked that the creator also focused on energy levels, which makes this formula possible for pre-workout and digestion, which many people struggle with when increasing protein intake.

It’s also nice to see that much of the existing research, though mixed at times, is based on Muscle Defense’s target population rather than a younger population of men. This goes to show that the formula under consideration has a lot of potential for making a positive difference. The fact that the founder underwent similar health discrepancies and was about to correct them in his later years makes Muscle Defense quite attractive as well. Who can forget his active involvement in the field of aging?

For those curious about the target population, Dr. Tracy Gapin insists that women, too, can benefit from Muscle Defense. However, our research only focused on men’s health; hence, we cannot say anything with certainty. For this reason, we encourage everyone to do their research before making any changes to their routine. Speaking of routine, Muscle Defense on its own is unlikely to make a lasting impression, necessitating a healthy diet and exercise routine as well. Visit the official website to learn more about Apex Labs’ and their Muscle Defense formula.