Top 13 Best Perimenopause Supplements to Ease Menopausal Symptoms (2024)

Most women know when they reach a certain age, they will begin menopause, and their hormone levels will change, leading to menopause symptoms. However, what many don’t know is that these symptoms can start while they are still going through their final menstrual cycles, in a period known as perimenopause.

Some women will seek out HRT (hormone replacement therapy) or similar alternative medicine to try and get ahead of these perimenopausal symptoms, but this is not always the best thing to do, as they can often cause side effects. Instead, consider using a natural perimenopause supplement.

The only issue is that menopause and perimenopause supplements contain various unusual ingredients, so knowing which to use can be challenging. That is why we have made the following list of the best menopause supplements on the market to support female health without you having to resort to hormone therapy.

The 13 Best Dietary Supplements To Ease Menopausal Symptoms

  • Best Perimenopause Supplements Overall – EstroCare
  • Best Probiotic for Perimenopause – Menofit Complete Probiotic
  • Runner Up – Happy Mammoth Hormone Harmony
  • Best For Stress – Gaia Herbs Women’s Balance
  • Best For Libido – Nutrafol Women’s Balance
  • Best For Stomach Cramps – HUM Fan Club
  • Best Supplement for perimenopause Weight Gain – Hourglass Fit
  • The Best Supplement for Menopause Brain Fog – Feedamind
  • Best Perimenopause Multivitamin – One A Day
  • Best Menopause Joint Pain Supplements – FlexAgain
  • Best for Perimenopause Sleep Issues – RestAgain
  • Best For Hot Flashes – Natures Aid Evening Primrose Oil
  • Best Budget Option – Amberen Perimenopause Relief

Estrocare – The Best Menopause Supplement Overall


Estrocare is a relatively new product, yet it has quickly established itself as the very best menopause supplement around. This is thanks mainly to a formula that contains optimal doses of a vast range of natural ingredients that have been clinically proven to treat menopausal symptoms from all angles.

Said formula includes DHEA, vitamin A, vitamin B6, vitamin B12, vitamin C, vitamin D, iron, zinc, black cohosh, red clover, ginseng extract, Bifidobacterium animalis, Lactobacillus gasseri, 5-HTP, chromium, soy isoflavones, calcium citrate, magnesium, maca root extract, and Siberian rhubarb extract.

DHEA (dehydroepiandrosterone) will regulate the production of sex hormones to prevent weight gain and depression and improve the heart, immune system, sexual organs, bone health and functions, insulin sensitivity, physical performance, and stamina.

The vitamins keep the bones, brain, eyes, immune system, lungs, joints, and skin healthy and functional, promote normal collagen formation, energy levels, mental clarity, and mood, prevent depression, brain fog, vitamin deficiencies, and other menopause symptoms, and support women’s health.

The minerals boost eye, skin, nail, immune, nerve, and bone health and function, nutrient absorption and sleep quality, and prevent hot flashes, tiredness, head and chest pains, weakness, mineral deficiencies, sleep issues, anxiety, mood swings, night sweats, inflammation, low libido, and fatigue.

Black cohosh, red clover extract, and soy isoflavones all reduce hot flashes, night sweats, and hormonal imbalances, while the latter two also help to keep the body and lungs healthy, especially in menopausal women who have asthma.

Siberian rhubarb extract can treat virtually all menopausal symptoms. In contrast, ginseng extract can help balance hormones, improve your cognitive functions, energy levels, and libido, and reduce fatigue, hot flashes, mood swings, sleeplessness, and vaginal dryness.

The two probiotics, Bifidobacterium animalis, and Lactobacillus gasseri, will then support the production of healthy bacteria in your body, leading to good gut health and digestion and combating vaginal dryness.

5-HTP and maca root extract can improve sleep quality and prevent or manage symptoms like hot flashes, headaches, and depression.

By combatting all of the mental and physical symptoms of menopause and not causing any side effects, Estrocare can provide women with complete relief from the condition, making it the very best dietary supplement to combat menopausal symptoms on the market today.


  • It contains a diverse range of optimally dosed, clinically proven ingredients
  • It supports women’s health and treats menopausal symptoms without putting you at an increased risk of experiencing side effects
  • 100 Percent natural


  • Reviews from past customers are pretty limited

Menofit Complete Probiotic – The Best Menopause Probiotic


A reduction in the healthy bacteria in your body causes many symptoms of the menopause. This includes things like vaginal atrophy, hot flashes, stomach cramps, digestive issues, and weight gain. If you are particularly struggling with these issues, probiotic supplements are an excellent way to go.

Menofit Complete Probiotic is the best choice in this area, as it contains some great probiotics, such as Bifidobacterium animalis, Lactobacillus gasseri, Lactobacillus plantarum, and Lactobacillus reuteri.

It then also features inulin, tocotrienols complex, calcium carbonate, grape seed extract, acacia gum, sunflower lecithin, red clover, bitter melon fruit extract, barberry extract, r-alpha-lipoic acid, chaste berry extract, dong quai root extract, magnolia bark extract, astaxanthin complex, zinc, vitamin C, vitamin D, vitamin K, and vitamins B1, B2, B6, B9, and B12.

The probiotics and prebiotics work together to support your gut health and combat the gastrointestinal and vaginal symptoms caused by menopause. At the same time, the other ingredients can help with things like hot flashes and muscle mass or bone loss.

Admittedly, not focusing solely on being a probiotic does mean Menofit Complete Probiotic spreads itself a little thin, as all of the ingredient dosages are a little low, so it does not deliver any of its benefits as effectively as it could.

However, if your sole focus is on combating menopausal vaginal or gastrointestinal issues, Menofit Complete Probiotic can still be one of the best supplements to try.


  • It contains varied prebiotics and probiotics to alleviate gastrointestinal and vaginal discomfort caused by menopause.
  • Includes additional ingredients to combat other symptoms


  • Many of the ingredient dosages are lower than required to produce optimal effects.

Happy Mammoth Hormone Harmony – The 2nd Best All-Round Menopause Supplement


Much like Estrocare, Happy Mammoth Hormone Harmony is a supplement that aims to combat many symptoms, including bloating, fluid retention, hot flashes, and sleep disturbances.

It contains maca root extract, American ginseng root extract, fennel seed extract, chamomile flower extract, broccoli sprout extract, berberine extract, chaste tree fruit extract, ashwagandha root extract, gymnema sylvestre extract, rhodiola rosea extract, wild yam root extract, and rosemary leaf extract.

Maca and ginseng root extracts were both present in Estrocare and again serve the same purpose here.

Fennel seed extract improves sexual functions and satisfaction, while chamomile flower extract is claimed to enhance its effects, reduce anxiety and stress, and promote relaxation and restorative sleep.

Broccoli sprout extract boosts bone and immune health and prevents arthritis, while berberine prevents high blood pressure, cholesterol, depression, inflammation, diabetes, and heart issues.

Chaste tree fruit extract and ashwagandha root extract can help prevent hot flashes, insomnia, stress, night sweats, and urinary tract issues, improve sexual and cognitive function, and help you get better sleep.

Gymnema sylvestre is said to lead to fewer hot flashes, mood swings, sleep, and sexual issues and aid weight loss. Rhodiola rosea is also said to support heart health and reduce stress, while both can help support normal psychological function.

Wild yam root extract is said to prevent bone loss, hot flashes, and stomach cramps and support normal muscle function, while rosemary leaf extract is said to restore optimal hormone levels.

Admittedly, some of the ingredients need more research, while others should be taken in larger doses, and there have even been some complaints about it causing people to gain weight.

However, if you want a supplement that combats menopausal symptoms from multiple angles but isn’t willing to try something that is brand new, Happy Mammoth Hormone Harmony is still an excellent option to consider.


  • Its diverse formula tackles menopause from all angles


  • Some ingredients need more research, while higher doses are required of others.
  • There have been complaints about it making some women gain weight

Gaia Herbs Women’s Balance – Best For Stress


Gaia Herb’s Women’s Balance is a vegan supplement that consists of liquid capsules filled with black cohosh, alfalfa leaf, red clover, oat seed extract, chaste tree berry extract, dandelion root, St John’s wort, vervain aerial parts, dandelion leaf, and sage leaf.

With most of the ingredients lumped in a proprietary blend, as well as having been in the other products we have looked at, we would not typically rank it so highly. However, the mix of ingredients it contains suggests it is well formulated to help relieve stress, an opinion that is backed up by customer reviews.

So, while it certainly will not be for everyone, if you are suffering from severe stress while going through menopause, Gaia Herbs Women’s Balance could be the ideal supplement to make you feel just a little bit better.


  • One of the best supplements to treat stress caused by irregular estrogen and testosterone levels


  • Most of its ingredients have their doses obscured in a proprietary blend, and some need more study.

Nutrafol Women’s Balance – Best For Libido


Nutrafol Women’s Balance is a supplement that tackles two of the least talked about yet most problematic symptoms of menopause: low libido and hair loss.

It uses vitamins A, B7, B12, C, D, and E, iodine, selenium, zinc, and proprietary blends of healthy fats from saw palmetto, maca, collagen, ashwagandha, curcumin, palm extract, grape seed extract, black and cayenne pepper, horsetail extract, and the amino acids l-lysine, l-cysteine and l-methionine.

While a number of these ingredients have been seen in the other supplements we have examined, their dosages and the ingredients that are mixed with them have been specifically tailored to promote a better sex drive and stronger hair follicles.

Admittedly, the use of a proprietary blend is concerning, as you don’t know all of the exact dosages of each ingredient. Some of the ingredients also need more research, and the product as a whole will not combat the full spectrum of menopausal symptoms.

However, if maintaining your hair or an active sex life are your primary concerns, Nutrafol Women’s Balance is one of the better options that you have at your disposal.


  • Very effective for improving your sex drive or hair health


  • It is not the most well-rounded supplement
  • Very expensive
  • Some of the ingredients need more research

HUM Fan Club – Best For Stomach Cramps


HUM Fan Club is a multi-symptom menopause relief supplement made using the simple formula of grape seed extract, Siberian rhubarb extract, and lactobacillus plantarum DR7. At first glance, it appears to be trying to do a little bit of everything, and given the description of the supplement, this may well be true.

However, regardless of what their intentions may have been, the three ingredients work in perfect sync with each other to combat the stomach pains and abdominal cramps that women often face during menopause.

So, while the dosages and ingredients present mean it will not be the right choice for every woman if you are explicitly trying to combat the stomach issues mentioned above, HUM Fan Club may be one of the best supplements for you to try.


  • Perfectly formulated to combat stomach cramps and abdominal pain


  • Ingredients and dosages are pretty limited
  • It will have minimal effect on any other menopause symptoms

Hourglass Fit – The Best Supplement To Prevent Menopause Weight Gain


Hourglass Fit is the best women’s weight loss supplement on the market, so it is ideal to stop you from gaining weight during menopause. It contains cayenne pepper extract, black pepper extract, glucomannan, 5-HTP, zinc, chromium, and vitamins B2, B6, and B12.

We’ve seen some of these before, and they’ll again help you get better sleep, improve your mood, focus, blood sugar levels, metabolism, relaxation, and brain, eye, and immune functions, and prevent anxiety, hunger, depression, mood swings, hot flashes, headaches, inflammation, weakness, and tiredness.

Glucomannan and cayenne pepper extract work together to mentally and physically suppress appetite and improve digestion, while the latter also aids fat loss and reduces inflammation and pain.

Black pepper extract also aids fat loss while boosting the bioavailability, absorption, and efficacy of the other ingredients. Vitamin B2 then increases coenzyme, antibody, and bodily tissue production, energy levels, digestion, metabolism, cellular respiration, and the health and repair of the body.

By supporting weight loss and combating the symptoms that occur when a woman’s estrogen levels decline, Hourglass Fit can prevent you from gaining weight during menopause or experiencing many other symptoms it can cause while being gluten-free and safe to use.


  • It is specifically designed to help women avoid gaining weight and stick to a healthy diet.
  • Uses only optimal doses of high-quality, clinically proven natural ingredients
  • Gluten-free


  • Quite pricey and not specifically designed to combat menopause symptoms
  • Must be bought directly from the official Hourglass Fit website

Feedamind – The Best Supplement for Menopause Brain Fog


Feedamind is a nootropic supplement that can help combat the cognitive issues that menopause can cause.

It uses a few ingredients we’ve already looked at in vitamins B6 and B12 and l-theanine, as well as n-acetyl l-tyrosine, bacopa monnieri extract, marigold flower extract, resveratrol, pterostilbene, alpha-GPC, oat straw extract, cat’s claw extract, vitamins B1 and B7, chocamine, and diamine.

Acetyl l-tyrosine boosts brain functions and stamina, neurotransmitter production, and relaxation, while it and bacopa monnieri extract both increase mental processing and health, reduce stress and anxiety, and keep the body healthy.

Marigold extract boosts mental processing speed and eye health and functions and prevents oxidative damage, stress, and inflammation. Resveratrol and pterostilbene reduce inflammation and oxidative stress and keep the gut, brain, nerves, joints, and body healthy and working correctly.

Alpha-GPC boosts brain health and functions, concentration, motivation, learning, muscle contractions, memory, nutrient metabolism, fat loss, and cholesterol levels.

Oat straw and cat’s claw extracts are said to reduce anxiety, brain plaque, mental decline, inflammation, stress, fatigue, and insomnia, improve mental clarity, memory, brain and body health, blood flow, mood, physical performance, and virility, and prevent cognitive decline and Alzheimer’s disease.

Vitamins B1 and B7 improve your growth, amino acid breakdown, mental energy, alertness, hair, nails, bone, and skin health. Chocamine and dynamine improve blood flow to the brain, mental energy, focus, brain functions, circulation, and heart health.

While admittedly, some of these ingredients do need a bit more research to confirm their full effects, Feedamind is still one of the best supplements for menopausal women suffering from the poor cognitive function that the condition can cause.


  • Contains a range of ingredients proven to support your brain health and functions from every angle


  • Some of the ingredients need a little more research to prove how effective they are

One A Day Women’s Menopause Multivitamin – The Best Menopause Multivitamin


One A Day Women’s Menopause Multivitamin is specifically designed as a budget-friendly supplement that every woman can afford.

It contains vitamins A, B1, B2, B3, B5, B6, B7, B9, B12, D, and E, zinc, calcium, copper, chromium, iodine, magnesium, manganese, molybdenum, selenium, powdered soy isoflavones, and a long list of ingredients to improve the taste and stability of the pills.

Almost all the vitamins and minerals are present in their recommended dosages, which makes it ideal to keep you healthy during menopause. However, it is not overly great for combatting menopausal symptoms once they have developed.

This means while it will not work for everyone, if you want a cheap supplement during perimenopause to prevent any symptoms from developing and keep you healthy without visiting your healthcare provider, One A Day Women’s Menopause Multivitamin is an excellent option to try.


  • Very affordable
  • The vitamins and minerals are all optimally dosed


  • Will not combat or cure menopausal symptoms once they have started

FlexAgain – Best For Menopause Joint Pain


FlexAgain is a joint supplement made from omega three fatty acids, glucosamine sulfate, curcumin extract, chondroitin sulfate, ginger and blue galangal extracts, bromelain, resveratrol, boswellic acid, MSM, vitamin K, and vitamin D that is ideal for combatting the joint pain low estrogen levels can cause.

As we saw in Estrocare, vitamin D prevents you from developing a vitamin deficiency and keeps your bones, joints, and body strong and healthy. Vitamin K does the same as vitamin D while making vitamin D easier to absorb and combating the spine and hip issues menopausal women face.

Glucosamine, chondroitin, and MSM reduce cartilage degradation, inflammation, and joint stiffness and pain, improve cartilage production, bone health, joint function, health, and lubrication, and work exceptionally well when used together.

Omega 3 fatty acids combat arthritis, inflammation, and joint pain and improve brain, muscle, and nerve functions, health, growth and repair, connective tissue and joint growth, lubrication, and flexibility.

Bromelain treats joint inflammation and pain, congestion, heartburn, and damaged cartilage and boosts heart, digestive, and immune health and functions and protein metabolism.

Ginger and blue galangal are root plants that can relieve joint pain and inflammation, repair damaged joints, improve the health and functions of the digestive and immune systems, and enhance nutrient absorption, and they work exceptionally well when used together.

Boswellic acid, curcumin, and resveratrol fight free radicals, oxidative damage, inflammation, joint pain and swelling, high blood pressure and cholesterol, arthritis, bone, joint, organ and cartilage damage, and some other health issues, and boost gut, heart, joint and nerve health and fat loss.

By tackling joint issues at the root cause of the problem, FlexAgain can provide all-around joint support, making it an ideal supplement for women suffering from joint pain caused by menopause.


  • It contains ingredients proven to keep the joints strong, healthy, and pain-free.
  • Optimal doses ensure maximum efficacy without causing side effects
  • Can combat some symptoms beyond joint pain


  • Quite expensive
  • Can only be bought directly from the official FlexAgain website

RestAgain – The Best Sleep Aid For Menopause


RestAgain is a potent sleep aid that can help combat the sleep issues that menopause can cause. It uses optimal doses of ashwagandha root, l-theanine, magnesium, valerian root, GABA, 5-HTP, calcium, melatonin, vitamin B6, vitamin B12, and vitamin D.

Ashwagandha, calcium, 5-HTP, l-theanine, vitamins B6 and B12, vitamin D, and magnesium contribute the same benefits they have in previous supplements, so they can reduce hot flashes, night sweats, hair and bone loss, sleep problems, and other symptoms, and support normal skin health.

Melatonin regulates your sleep-wake cycle, improves sleep latency, and promotes REM sleep (rapid eye movement sleep), the most restful type.

GABA helps you relax and reduces stress and anxiety, while valerian root boosts your natural GABA production, providing similar effects and making GABA even more potent(.

By supporting sleep from every angle, RestAgain promotes good quality sleep and prevents issues like hormone imbalances, hot flashes, or night sweats from stopping you from sleeping. Reasonably priced and side effect-free, it is ideal for preventing or treating menopausal sleep problems.


  • The most substantial sleep aid you can get without visiting a healthcare provider
  • Improves sleep from every angle
  • Uses high quality, optimally dosed ingredients proven to work without causing side effects
  • Very reasonably priced


  • Customer reviews are hard to find
  • Must be purchased directly from the official RestAgain website

Natures Aid Evening Primrose Oil – Best For Hot Flashes


Evening primrose oil is one of the most effective ways to treat hot flashes, and the Natures Aid supplement contains nothing but the active ingredient in its purest form.

Admittedly, it is of no use for virtually any other symptoms of the menopause. However, with its low price tag and very favorable reviews, if combatting hot flashes is your primary concern, it is still one of the best options for you to try.


  • Reasonably priced and great for hot flashes


  • It will not help with any other menopausal symptoms

Amberen Perimenopause Relief – Best Budget Option


Amberen Perimenopause Relief is specifically designed as a low-cost supplement for women just entering menopause, and it aims to combat their symptoms as early as possible. It contains vitamins B1, B2, B6, B9, B12, and E and a proprietary blend of minerals, salts, and the amino acid glycine.

Admittedly, many of the ingredients need more research to prove how effective they are. However, if you are specifically seeking a reasonably priced perimenopause supplement, Amberen Perimenopause Relief is still one of the best options to try.


  • Very reasonably priced


  • It uses a proprietary blend
  • Many of its ingredients need to be researched more thoroughly

The 13 Best Supplements To Ease Menopausal Symptoms Conclusion

Perimenopause supplements are a great way to help treat or prevent menopause symptoms as early as your last menstrual cycle without resorting to hormone therapy or another alternative medicine. While there are several excellent options for you to pick from, the best choice for most women is Estrocare.

It contains a blend of optimally dosed active botanicals, amino acids, hormones, vitamins, minerals, and healthy gut bacteria, each of which a healthcare professional has conducted extensive research on, so it can support well-being, optimal health, and symptom relief for all women going through the menopause.

If it doesn’t sound like the right choice for you, then one of the other dietary supplements on our list surely will do. For everyone else, though, we highly recommend that you give Estrocare a try and see how well it can restore normal function without having to turn to hormone therapy for yourself.


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