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Best Longevity Supplements for Life-Extending Healthy Aging Benefits

June 21, 2024 1:30 am
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Best Longevity Supplements

Are there really health benefits to healthy aging supplements, or is living a healthy life enough?

Everybody wants to live a healthier life, whether you go out running everyday and eat healthy foods or have a less active lifestyle and prefer a hearty burger. We all know how to live a healthier life as well, though we may not always be completely honest with ourselves about that. The problem is that it’s very difficult to keep on top of everything, especially when it comes to nutrition, and stressing about it kind of defeats the object, as stress is terrible for health. So what’s the solution?

Well the way we see it, you’ve got two options. You can either pay for a health and fitness instructor to create a strict plan for you to stick to, which can cost a lot of money, or instead lean on a new trend of natural longeveity supplements. Unfortunately that’s where you run into more problems, as similar to other dietary supplements there’s just as many poor products as there are great, but they all claim to be the very best. How are you supposed to tell them apart without hours and hours of research, that none of us have the time to do?

Well that’s exactly why we’ve brought this article to you today, combining expert industry knowledge with our top research team in order to determine which products are really worth your time. Now unfortunately we weren’t able to find any miracles, but we got pretty close with some surprisingly capable formula. Let’s now waste anymore time and get stuck into it.

Our Choices for The Best Life Extending Supplements

Prime Male Life – The Best Longevity Supplement

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Prime male have provided us with many great supplements, with our main favorites being their T-Vitamins and Vitality blends. Their latest product however steps away from their usual punching ground of testosterone boosters, as they’ve spread their wings into the longevity supplements market with Prime Male Life.

One thing that’s clear right out of the gate is that these guys really know what they’re doing, and though that may be surprising given it’s their first attempt, their track record is evidence enough that they’re clearly got a great and knowledgeable team behind them. This natural health supplement brings with it everything you’d want for improving longevity, such as maintaining bone health which in itself is a fantastic way to promote healthy aging and keep that youthful vim and vigor for much later in life. This is done by not only a great collection of single ingredients, but in the way said ingredients work together to enhance the overall potency of the formula, showcasing their commitment to excellence.

Pros:

  • Fantastic formula
  • Highly dosed ingredients
  • 100% natural
  • Transparent labeling
  • Clinically proven to be effective
  • High quality sources
  • Made in FDA approved facilities
  • Best Overall longevity supplement

Cons:

  • New product means low consumer feedback at present

Ingredients Breakdown

Hyaluronic Acid (As Sodium Hyaluronate) – 200mg

One of the most common ways people try to prevent aging is via their skin, with everything from face cream and moisturizers to paralytic injections such as Botox being sold exactly to tackle this problem. The reason skin looks youthful is quite a complicated question, but one of the main contributing factors here is that youthful skin retains a high amount of water thanks to a high concentration of hyaluronic acid.

The well-documented anti-aging benefits of topical application on skin are also achieved through oral supplementation with sodium hyaluronate. Czech researchers in 2017 discovered that sodium hyaluronate could be vital in both preventing skin damage and aiding in its treatment, due to its hydrating, regenerative, and defensive properties. Another study in 2024 revealed that the use of SH supplements could potentially prolong life.

Nicotinamide Riboside (NR) – 700mg

Whilst it might be true that this ingredient is a great source of vitamin B3, it’s got many health benefits that can support healthy aging and longevity of life that make it far more than that.

Clinical trials show that Nicotinamide Riboside offers health benefits by protecting against diabetes, Alzheimer’s, endothelial dysfunction, and inflammation. It’s also great for gut health, as this same trial found it was able to reverse gut dysbiosis and promoted all around intestinal and extraintestinal well-being.

Trimethylglycine / Betaine Anhydrous – 800mg

This nutrient is very versatile, being used by the body in everything from cellular reproduction, liver function and the synthesis of carnitine, as well as helping the body metabolize important amino acids such as homocysteine. You can see how it might make its way into a longevity supplement then, as it has many ways of promoting healthy aging, and is typically found in the best anti aging supplements around.

We found a comprehensive review that found Betaine Anhydrous offers offers diverse health benefits, including liver protection, prevention of fatty liver disease, promoting brain health, pancreatic health, preventing cancer development and mitigation of oxidative stress inflammation

Resveratrol – 500mg

While it might be said in a playful manner, if you ask many of the older generation what their secret to long life is, they might tell you it’s a cheeky glass of wine every night. The thing is, there’s actually a glimmer of truth to this, as you can see with how abundant resveratrol is in red wine, which is known to have potent antioxidant effects as well as a plethora of other health benefits.

This powerful antioxidant activity provides potent anti-inflammatory, anti-cancer, anti-diabetic, cardio-protective, anti-obesity, and neuroprotective effects, and clinical trials have shown it’s positive impact on cognitive health, menopause, bone health, cardiovascular health, glucose metabolism, sport nutrition, and skin health.

Berberine – 500mg

While this natural compound found in plants offers a wide array of health benefits, including antioxidant and anti-inflammatory effects, its most helpful function for longevity supplements is how it interacts with our metabolism. It’s able to regulate important processes such as insulin secretion and gut microbiome balance, making it an excellent answer to diabetes effects.

Clinical studies have shown Berberine can significantly improve health thanks to its large impact on blood glucose levels, insulin sensitivity and resistance, blood pressure, body composition and inflammatory markers without a sign of any form of human intolerance, with surprisingly not a single unintended effect being reported by the researchers

Quercetin – 400mg

Similar to resveratrol, quercetin is highly abundant in grapes and as such, red wine, though it’s also found in many other fruits and vegetables as well as green tea. The anti-inflammatory and antioxidant effects here are well documented, with more and more positive data being added to the table with each passing year showing this flavonoid can do a lot more than just combat oxidative stress.

It’s been found to have potent anti-cancer properties owing to how effectively it deals with free radicals, as well reducing the effects of brain aging thanks to its neuroprotective effects resulting in a great preventative measure to those worried about Alzheimer’s disease and dementia. On top of all of this it’s been found to help with wound healing as well as providing great cardiovascular support.

Alpha Lipoic Acid -500mg

Whilst it may be difficult to believe, every single cell in your body contains alpha lipoic acid, working as a sort of end point within glucose metabolism as it converts the glucose into energy the cells can use, making it crucial to healthy cell function and cellular energy production. Though our body is able to synthesize alpha lipoic acid, our ability to do this diminishes over time, making energy production at a cellular level more and more difficult. Luckily it is dietarily available, though it’s content in food isn’t regularly listed, making tracking our intake close to impossible. In terms of supplementation, it’s mainly thought of as an antioxidant, but as its function in the body might suggest there’s clearly a lot more going on here, and recent scientific data shows a lot of promise.

A clinical review we found highlights this, with the researchers finding that Alpha Lipoic Acid not only supports antioxidant functions, but also aids in vision health, protects cellular health from free radicals, helps to ensure the liver can function properly, and helps to dissolve toxins within the body.

Fisetin – 100mg

Whilst it’s definitely rare to find positive data of anything directly having the ability to extend lifespan, Fisetin is the exception. This links in with what’s known as the free radical theory of aging, which suggests that the accumulation of oxidative damage is a major cause of aging and as such, reduced risk of oxidative damage can somewhat slow down the rate we age.

Fisetin seems to be proving this theory as correct, as although UV irradiation was not affected by fisetin, it significantly reduced the presence of reactive oxygen species (ROS) in cells, as well as a notable increased resistance to oxidative stress, improving cellular health. Age related decline in motility was also delayed by supplementation with Fisetin. Not stopping there it was also found to inhibit the decline of neurons, with it being found to significantly slow the degeneration brought on by degenerative diseases such as parkinsons.

Vegan Collagen – 200mg

When comparing people of the same age and noting their health, something that is extremely common is that those in better health simply move around a lot more, even when that’s something as simple as an aerobics class or daily, casual walks. This is because of course the more we move around, the better our joint and muscle health, offsetting the effects of atrophy.

This is one of the ways collagen supplementation can help us live a long and healthy life. It’s well known that collagen is present within bones and joint cartilage, and research has found that collagen aids help with joint health by slowing cartilage degradation, reducing inflammation and pain, and improving joint function.

Verdict

It’s probably quite clear already but it needs to be said, we’re very impressed with Prime Male life. It’s not often a company can come out swinging like this but Prime Male have hit it out of the park, with a great collection of clinically proven ingredients and no fluff and no gimmicks. We can’t wait to see what comes next for these guys, and if you like what you see here today then we highly recommend you pick up Prime Male Life.

Browse Prime Male Life Deals Here >>>

Hunter Focus – The Best Nootropic Longevity Supplement

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We’ve always liked HunterEvolve, as they have a fairly unique approach to dietary supplements that distinguishes themselves for the pack. Where most have bigger marketing budgets than they have any right to, HunterEvolve instead allocates the majority of their resources to research and development. This allows them to create astonishingly potent formulas with the highest doses around, with ingredients that would normally exceed the budget of their contemporaries. There is a downside to this as well unfortunately, as is the case with any premium product like this there is a higher price point to match. The way we see it however is it’s all about value for money, and that’s something you get with Hunter Evolve.

Their nootropic Hunter Focus follows this trend, having a large ingredients list without scrimping on the doses, as well as having some of the best ingredients available. Where some lesser nootropics function as basic stimulants with some extra, Hunter Focus focuses on healthy aging within the brain, with many of the ingredients here providing protection in the brain against neurodegenerative diseases.

Pros:

  • Fantastic formula
  • Highly dosed ingredients
  • 100% natural
  • Transparent labeling
  • Clinically proven to be effective
  • High quality sources
  • Made in FDA approved facilities
  • Great consumer feedback
  • The best nootropic longevity supplement

Cons:

  • Serving size requires 6 capsules

Ingredients Breakdown

2.5mg of Vitamin B6

B Vitamins are categorized by their roles in metabolism and energy production, such as vitamin B6 here being an essential component of over 70 different enzyme reactions from amino acid metabolism, folate metabolism, protein synthesis and immune function.

Clinically Vitamin B6 has been shown to so much as reduce anxiety and strengthen visual surround suppression, as well as inducing a trend towards reduced depression.

100mcg of Vitamin B9

Just as Vitamin B6, Vitamin B9 helps to ensure our metabolism is functioning properly, this time being integral to the creation of DNA and RNA, something our bodies need as much help with as they can get as we age.

A review we found analyzing the efficacy of vitamin B9 to manage neurocognitive disorders looked at 36 total articles, and the research suggests Vitamin B9 supplementation improves cognitive function, vascular care, inflammatory status and antioxidant responses.

7.5mcg of Vitamin B12

Arguably one of the most important essential vitamins for good brain health, Vitamin B12 is notable for its effects on healthy red blood cell formation, DNA synthesis and the development and function of the central nervous system.

The studies that show vitamin B12 is an effective nootropic are plentiful, and most telling are the studies into vitamin B12’s interaction with homocysteine, in which high levels in the brain are linked to an increased risk of dementia and Alzheimer’s disease. B12 deficiency is linked to higher than normal levels of homocysteine in the body, and the researchers in this paper stated that awareness should be raised among clinicians in order to accurately diagnose and treat early vitamin B12 deficiency to prevent irreversible brain damage.

75mcg of Vitamin D3

Vitamin D3 is the easiest form of dietary Vitamin D for our bodies to absorb, owing to Hunter Focus’s endeavor to only have the best ingredients. We typically get our Vitamin D from the sun, which is why some refer to it as the “sunshine vitamin”, though unfortunately as our lives have become more and more separated from being outside a lot, deficiency is now very common. You may think that sitting by the windows in your office is going to help, but unfortunately the rays necessary to Vitamin D synthesis are blocked by windows.

As this review we found points out, the main reason it’s so important for brain health is because it has so many important roles within the brain, such as calcium signaling, neuroprotective actions, neurotransmission and synaptic plasticity, and the researcher points out that an increasing number of studies indicate that vitamin D deficiency is associated with a wide range of psychiatric disorders and neurodegenerative diseases.

100mcg of Vitamin K2

Whilst we typically either make our own essential vitamins or get the majority of them from dietary means, Vitamin K2 is different in that it’s actually produced by gut bacteria. Now we don’t quite get enough, but it’s relatively easy to get enough from our diet without thinking about it very much as our needs are quite low. That being said, getting more of it than you necessarily need is advantageous in many ways.

Vitamin K supplementation has been commonly found to enhance energy levels, cognitive function and overall brain health. This is because it’s been found to activate a protein known as Gas6 which supports brain function and inhibits neurodegenerative diseases, as well as it’s ability to seemingly reverse the calcification of blood vessels, helping to counteract cardiovascular disorders which are associated with conditions such as hypertension and stroke.

Vitamin C 200mg

A commonly known and very essential Vitamin, ascorbic acid (also known as Vitamin C) is responsible for many important functions within the body, and though deficiency is rare the results are devastating.

Its functions as a nootropic are less well known, but there’s been mounting evidence for it over the years making it a much more common sight in brain health supplements in recent years. One such study found that vitamin C reduced oxidative stress, mitochondrial dysfunction and cognitive impairment thanks to the attenuation of isoflurane-induced caspase-3 activation which is known to cause cognitive impairments.

Acetyl-L-Carnitine 800mg

This ingredient has a rare trait in that it’s able to pass the blood brain barrier and is essential for the proper functioning of mitochondria in the brain.

It’s largely considered an effective nootropic within scientific circles, with studies finding that it has multifaceted benefits on cognitive function. It has antioxidant and neuroprotective traits to help slow cognitive decline thanks to its ability to reduce the amount of oxygen consumed for the energy supply needs of the nervous system. This has been found to enhance synaptic transmission and mood regulating effects, with the scientists proposing it’s use in the treatment of depression.

L-Tyrosine 500mg

Largely associated with its role in regulating stress and our “fight or flight” response, which as we’re all aware can have a major impact on our aging process. The more stress we feel can heavily impact and speed up our aging in many different ways, but one of the most impactful are the effects on catecholamine levels. Luckily L-Tyrosine regulates stress by increasing our catecholamine levels, reducing and possibly even reversing the effects of stress on our aging.

It’s been clinically proven to have various advantages for overall well-being, including enhancing sleep quality which is incredibly important to health and longevity. This is thought to be because L-Tyrosine is a precursor to dopamine and norepinephrine which both play a role in stress response to help ensure we get a good night’s rest

200mg of L-Theanine

We all associate Green Tea with a feeling of calm serenity, though we’ve long known that the cause of this is because Green Tea is abundant with the amino acid L-Theanine. It’s long been known that a dose of around 100mg of L-Theanine will have anti-anxiety and anti-stress effects, though 200mg is sure to have a stronger effect without any increased risk of side effects. It’s actually typically found in popular sleep aids such as RestAgain because it’s calming effects can help to induce sleep without any feelings of drowsiness, though when used in conjunction with caffeine as it is in Hunter Focus, it’s been known to invoke a sense of tranquil and sustained vigor with enhanced concentration and vigor.

Citicoline 250mg

Citicoline is a substance found in the brain that is recognized for its regenerative effects. It is also credited for a variety of brain-enhancing advantages that can ultimately result in enhanced overall cognition, increased energy, and improved memory thanks to it’s ability to improve blood flow to the brain.

The evidence and information backing its utilization are currently in the early stages, but there is an increasing amount of data indicating that it is a valuable addition. Based on the available knowledge, a dosage of 250mg appears to be ideal.

Lion’s Mane Extract 500mg

Thanks to its abundance of bioactive compounds such as herinones, erinacines and many more, Lion’s Mane Extract has become a very popular nootropic ingredient in recent years. These compounds are known to stimulate nerve growth factor synthesis, potentially aiding in conditions that cause cognitive decline such as dementia and parkinson’s disease.

There is some contradicting evidence but this comes from low quality studies for the most part, and none have successfully dismissed Lions Mane Extracts ability to stimulate nerve growth factor, which is a mechanism that would in theory support the claims made by clinical studies that claim Lions Mane is effective.

Bacopa Monnieri 300mg

The amount of Bacopa HunterEvolve have provided us with here is very generous and is a great showcase of their high dosage approach to dietary supplements. It was historically used to help Vedic scholars to memorize lengthy and sacred hymns and scriptures, and its use really hasn’t changed all that much as today, Bacopa is mainly known for its aid in memory and focus, and anti-depression effects.

We found a 12 week study aiming to elucidate the effects of bacopa on attention, cognitive processing, and working memory in elderly volunteers, and by the end of the study they found significant improvements in all three areas without a single side effect being observed throughout the entire experiment.

Ashwagandha 300mg

Hailing from Africa and Asia, this evergreen shrub is one of the most common ingredients in the best nootropic supplements. Though its use was once considered as everything from an aphrodisiac, tonic, stimulant, narcotic and diuretic, it’s most commonly associated nowadays with inducing a calm state.

Clinically it’s safely regarded as effective by the highest quality research papers, such as this randomized, double-blind, placebo-controlled study that provided the intervention group with the 300mg dose you see in Hunter Focus over 90 days. Of the 125 subjects to have completed this long study, it was found that there was a significant difference between placebo and intervention groups in everything from improved memory recall, lower cortisol levels, improved sleep quality and higher scores on a happiness questionnaire, suggesting significantly lower stress levels and better psychological well being in those taking 300mg of Ashwagandha. Across the whole 90 days not a single adverse effect was reported.

Caffeine 100mg

Caffeine can be a bit of a contentious ingredient in nootropics and dietary supplements, as some people can be quite sensitive to the effects. When you look at how much other companies choose to put in, you can see how this is something that some just simply can not risk without suffering some sort of reaction, but HunterEvolve have chosen a drastically reduced amount here. 100mg is less than a typical cup of coffee, so if you’re sensitive but you can manage it, then Hunters dosing here will be just right for you. Another reason we really like that they did this is because commonly people who enjoy drinking coffee are unable to do so when taking a supplement with caffeine. This amount would be somewhat similar to drinking two cups of coffee, so if this is something you regularly do, you’ll still be able to enjoy a single cup, though we would recommend leaving some time between your Hunter Focus and your coffee.

A study we found took forty five healthy adults and in those provided caffeine an improvement was found in many different aspects of their visits to the clinic, including improved cognitive flexibility, executive function, sustained attention, motor speed, psychomotor speed compared with placebo. Further than that, researchers also found and increase in overall activity and even friendliness in the caffeine group

Ginkgo Biloba 120mg

One of the most fascinating things about the ginkgo tree is that its leaves have been found fossilized that date back to times before even the dinosaurs. Whilst we mostly think of Ginkgo Biloba as a cognitive enhancer, it was used in traditional Chinese medicine as a treatment for asthma, bronchitis, kidney and bladder disorders.

A 2008 review we found described the plentiful positive effects ginkgo has on cognition, all in the absence of adverse effects. They describe that the neuroprotector effect of these drugs is based on the antioxidant properties, as well as the ability to normalize energy transfer mechanisms in cerebral neurons.

Phosphatidylserine 100mg

This substance can be found in food, although its presence is limited. It is commonly acknowledged as a crucial element for optimal cognitive performance, which is why it is often included in new nootropic products, though none have quite as much as Hunter Focus reminding us that they are in fact the highest dosed supplement.

In recent years, the nootropic ingredient known as phosphatidylserine has gained significant attention due to research studies showcasing its potential to enhance mood, decrease stress, and potentially enhance focus and concentration such as a review we found.

Maritime Pine Bark 75mg

One common running thread you’ve likely realized already is that longevity supplements are typically jam packed with antioxidants. Maritime Pine Bark is another such ingredient, but similar to Acetyl-L-Carnitine can cross the blood brain barrier. It can stimulate and increase blood flow to the brain thanks to it’s production of nitric oxide, providing more energy via an increased supply of oxygen to the brain.

Studies show that incorporating Maritime Pine Bark into your daily routine will result in increased concentration, improved mental clarity, enhanced brain function, better memory, and can even slow the aging process within the brain.

Rhodiola Rosea 50mg

Used in western Europe as a traditional medicine, Rhodiola Rosea was once thought to treat everything from fatigue, depression, nervous system disorders, as well as promoting extended physical endurance, longevity and work productivity.

While there have been various studies indicating its potential for promoting overall health, its use as a nootropic is primarily focused on enhancing mood and decreasing stress due to its adaptogenic properties. It’s been clinical observed to counteract depression and provide neuroprotective and pro-cognitive effects thanks for the regulation of reactive oxygen species and increase brain-derived neurotrophic factor levels, which are essential for cognitive function

Panax Ginseng 40mg (10:1)

A common sight in nootropic supplements, although HunterEvolve has pushed things quite a bit further by providing quite possibly the highest dose we’ve ever seen. It might not look like much at 40mg, but the 10:1 concentration means you’re actually getting an equivalent dose of 400mg.

Panax Ginseng is known for its numerous physical and cognitive enhancing advantages, making it a popular ingredient in a wide variety of health supplements, including those for nootropic purposes. With that being mentioned, this substance is recognized for its ability to enhance cognition. While it does provide physical benefits, it is recommended to aim for a daily intake of approximately 300mg (and possibly up to 1000mg for treating certain conditions). However, studies have shown that a dosage of 40mg can still provide cognitive benefits if the bioavailability is high.

Spanish Sage 25mg (4:1)

Limited evidence exists for our last ingredient, however Spanish Sage has been utilized in the past few decades to enhance memory and recollection. There are several intriguing studies that demonstrate a significant correlation between its usage and a notable advancement in these aspects.

By using a 4:1 extract, the dosage of Spanish Sage is equivalent to 100mg and while it may not be a common ingredient in most nootropics, it is a valuable addition to the blend.

Verdict

Talk about a premium product, HunterEvolve has provided us with yet another fantastic supplement with Hunter Focus. Lots of clinically proven ingredients here with higher doses than you’ll get elsewhere. Though they’ve advised on their website that it can take a few months to kick in, most of us felt effects right away, which was exciting as it seems to be that these effects will only improve as we continue to take Hunter Focus daily. These supplements will affect everyone differently, but if you’re focused on enhancing and protecting your brain power then Hunter Focus is going to have the biggest impact you could ask for.

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GenuinePurity Liposomal NMN – The Best Single Ingredients Longevity Supplement

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The most impressive thing when it comes to GenuinePurity (other than their fantastic supplements) is their reputation. After 24 years in business you might expect a scandal or two, but GenuinePurity are spotless, showing their passion for greatness and professionalism. Their supplements are much simpler than the other options on this list, containing only one ingredient a piece, but some people prefer that simplicity so we thought it’d be a great inclusion for today.

Pros:

  • Simple formula
  • Highly dosed ingredient
  • 100% natural
  • Transparent labeling
  • Clinically proven to be effective
  • High quality sources
  • Made in FDA approved facilities
  • Great consumer feedback
  • Best single ingredient longevity supplement

Cons:

  • Single focused design
  • High price point for a single ingredient

Ingredients Breakdown

Liposomal NMN 250mg

There’s a metabolite in our body that is quite possibly the most crucial of them all, and it’s name is Nicotinamide Adenine Dinucleotide (NAD+). Being responsible for over 500 coenzyme reactions, this important molecule plays roles in everything from DNA repair, cell signaling. Recent studies suggest that maintaining optimal levels of NAD+ is crucial for cellular health, though it’s known to reduce as we age.

What they’ve done here is employed new technology in the medical/ pharmaceutical world that involves encapsulating Nicotinamide Mononucleotide (NMN) in what are known as liposomal nanoparticles, which were discovered to mimic the bodies own molecule transport system.

As a precursor to NAD+, supplementing with Liposomal NMN has been observed to be a great way to ensure you maintain optimal levels, helping to effectively slow the aging process.

Verdict

We recognise that there might be a bit less going on here than the other supplements we’ve brought to your attention, but what you’re getting is on the absolute edge of technological advancement in nutritional supplements as well as simply providing a fantastic, all encompassing way to slow aging. The price is also quite similar which could put some off as you feel you’re maybe getting more with the other options, but here you are definitely getting a great longevity supplement and is a clinical proven solution.

Browse Liposomal NMN Deals Here >>>

Nootrum – The Best Mushroom Longevity Supplement

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In recent years there’s been a large increase of mushroom supplements and after keeping an eye on it, it’s certainly nootrum that have risen to the top as the very best around. They have everything from mushroom coffee, mushroom powder and more, but what we’re discussing today is their capsules. We feel like this is their best product overall, though their full collection is worth a look if this piques your interest.

Whilst we’ve long known Mushrooms to be a healthy food, more recently there’s been further studies into exactly why they’re so healthy, and one of the most consistent findings are the ways they can slow aging. In fact, they’ve long been used in eastern cultures as anti aging products, and could realistically be a piece in the puzzle into why these cultures often age so gracefully.

Pros:

  • Fantastic formula
  • Highly dosed ingredients
  • 100% natural
  • Clinically proven to be effective
  • High quality sources
  • Made in FDA approved facilities
  • Great consumer feedback
  • Best mushroom longevity supplement

Cons:

  • Partial proprietary blend

Ingredients Breakdown

Vitamin D 15mcg

As we mentioned previously this Vitamin is essential to our health, having many important roles within the brain, such as calcium signaling, neuroprotective actions, neurotransmission and synaptic plasticity

Lion’s Mane Extract 266mg (20:1)

Lion’s Mane extract is rich in bioactive compounds such as hericenones, erinacines and many more (with much more difficult to spell names) which are known to stimulate nerve growth factor synthesis, potentially aiding in conditions that cause cognitive decline such as dementia and parkinson’s disease.

What’s notable here is the incredibly high dose, providing much more than you’d receive elsewhere.

Reishi Extract 266mg (20:1)

Reishi has long been known to support immune function and brain health in traditional Chinese medicine, being called the “immortality mushroom” for the ways it can enhance health and wellbeing.

Recent studies show how Reishi extract demonstrates antiaging properties, cognitive enhancement, neuroprotection, and even the potential to prevent or reverse memory disorders. It’s known to have antioxidant, anti inflammatory and immune boosting effects, to the degree that in vitro studies suggested it was effective at preventing corona virus infection.

Cordyceps Militaris 266mg (20:1)

Being used far into the past, Cordyceps has long been thought of as a medicinal fungus. Traditional healers in Sikkim recommended Cordyceps as an “all illnesses” tonic, claiming it could improve energy, appetite, fatigue, libido, endurance and sleeping patterns.

The benefits of Cordyceps are far-reaching and they have a profound effect on longevity, as they are packed with antioxidants that fight free radicals and slow down the aging process. The mushroom’s properties also aid in maintaining a healthy heart by reducing cholesterol levels and preventing atherosclerosis, a condition characterized by the hardening of arteries and improving blood flow of the heart and brain.

Shiitake Extract 266mg (20:1)

It’s long been thought that the longevity of many Eastern cultures can be traced back to their regular consumption of shiitake mushrooms. It has been used extensively in traditional asian medicine, and even to this day receives a large amount of attention in clinical studies as they find new ways it might be beneficial, such as the limited evidence for it being beneficial against cancer and other diseases.

The unique compounds found in this fungi, such as eritadenine and b-glucan, have been scientifically proven to reduce cholesterol levels and boost heart health. Moreover, the high concentration of B vitamins in shiitakes supports cognitive function by aiding neurotransmitter processes and reducing oxidative stress in the brain. This not only enhances mental clarity but also helps to ward off neurological diseases . The anti-inflammatory properties of shiitake mushrooms are also worth mentioning, aiding in overall health and wellbeing but also providing extra benefits for individuals suffering from chronic inflammatory conditions such as arthritis or inflammatory bowel disease.

Proprietary Blend 266mg

A proprietary blend is always a bit worrying to see, as its most often used as a way to hide poor dosing decisions. This could be the case here, although we’re less worried as not only are you getting a lot with the previously discussed ingredients, but the ingredients present here are less crucial to the overall function of the supplement.

As is standard with all proprietary blends, they’re listed in descending order of what’s most prevalent in the blend, meaning what’s first is most plentiful, and what’s last has the lowest dose. In order then, the ingredients present here are Maitake Mushroom Extract, Turkey Tail Extract, Chaga Mushroom Extract, Royal Sun Agaricus Extract, White Button Mushroom Extract, and Black Fungus Extract.

These are all known to have overarching health benefits, such as Maitake having an abundance of antioxidants, beta-glucan, vitamins and minerals making it excellent for overall health. There’s also Turkey Tail which is similar in it’s high antioxidant and beta-glucan levels.

This is why it’s less worrisome here than other supplements that employ a proprietary blend, as its mainly just a bit of support for the main body of the supplement. It comes across less of a way to hide poor dosing decisions and instead more of a sake of convenient sourcing or efficient cost, as it’s likely this blend came as is for nootrum to add a cherry on top of an already great formula.

Verdict

There’s no denying that the science adds up, Nootrum does work and with its impressive formula of clinically backed mushroom extracts it’s our current favorite. The reason isn’t just the great formula, but the way it’s been dosed, and that’s something we’ve never said about a product that contains a proprietary blend before. The 20:1 concentrations provided for Cordyceps, Reishi, Shiitake and Lions Mane are enough alone to propel Nootrums capsules to the top, so it’s more like the proprietary blend is just a little extra on top of an already fantastic formula.

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